Oxalyl chloride → HCID 21110068、化合物

HRID 1766152ノート

反応式

HRID 1766152 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]1([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3C(C(O)=O)=[CH:18]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][N:8]=1>ClCCl>[ClH:4].[Cl:4][C:2]([C:1]1[C:20]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[N:17]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:18]=1)=[O:3]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 211100551-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

生成物 1

HCID 21110068HCID 21110068、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

0.61 cm3 (6.91 mmol) of oxalyl chloride was added, at a temperature in the region of 20° C., to 1.0 g (3.46 mmol) of 1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid in suspension in 30 cm3 of dichloromethane. After stirring at a temperature in the region of 20° C. for 2 h, the reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa) and used directly in the following stage.

後処理

  1. concentrationthe reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa)

出典と根拠

ORDレコード
ord-f4e84914bb324b0297ad8789583398df
出典データセット
uspto-grants-2007_06
特許番号
US07230007B2

反応ノート

読み込み中…