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Cyclopropanemethanol → 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropanemethanol | HCID 75644 | — |
| 反応物 | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | 1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) | HCID 21109693 | — |
| 生成物 | 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide | HCID 67012784 | — |
反応手順
The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-aminomethyl-cyclopentanol hydrochloride (CAS [76066-27-8]) as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide. MS (ISP) 385.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07229999B2 |
| 出典データセット | uspto-grants-2007_06 |
| ORD ID | ord-871e7b07416649d5a4cece42dc05d711 |
| 出典メモ | uspto-grants-2007_06 |