huagongshe.com
HRID1766554

反应详情

EQUATION

反应方程式

HRID 1766554 的结构方程式

REACTANTS

反应物

4
结构：OCC1CC1
HCID75644

Cyclopropylmethanol

C4H8O

结构：O=C(O)c1cnc(Cl)c(Br)c1
HCID285433

5-bromo-6-chloronicotinic acid

C6H3BrClNO2

结构：OB(O)c1ccc(F)cc1
HCID285645

4-Fluorophenylboronic acid

C6H6BFO2

结构：Cl.NCC1(O)CCCC1
HCID21109693

1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1)

C6H14ClNO

PRODUCTS

生成物

1
结构：O=C(NCC1(O)CCCC1)c1cnc(OCC2CC2)c(-c2ccc(F)cc2)c1
HCID67012784

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in analogy to Example 75, using 5-bromo-6-chloro-3-pyridinecarboxylic acid, hydroxymethyl-cyclopropan, 4-fluorophenylboronic acid and 1-aminomethyl-cyclopentanol hydrochloride (CAS [76066-27-8]) as starting materials to yield 6-cyclopropylmethoxy-5-(4-fluoro-phenyl)-N-(1-hydroxy-cyclopentylmethyl)-nicotinamide. MS (ISP) 385.3 (M+H)+.

WORKUP

后处理

  1. customThe title compound was synthesized in analogy to Example 75