Hydrochloric Acid → HCID 23031104、化合物

HRID 1766647ノート

反応式

HRID 1766647 の反応式
C[O:2][C:3]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)=[CH:7][C:4]=1[CH:5]=[O:6].B(Cl)(Cl)Cl.CO.Cl>ClCCl>[OH:2][C:3]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:20]([CH3:21])=[CH:19][C:18]([N+:22]([O-:24])=[O:23])=[C:17]3[C:13]=2[CH2:14][CH2:15][CH2:16]3)=[CH:7][C:4]=1[CH:5]=[O:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 25135Boron TrichlorideHCID 230312052-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy)benzaldehyde

生成物 1

HCID 23031104HCID 23031104、化合物収率 74.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2-Methoxy-5-(5-methyl-7-nitroindan-4-yloxy) benzaldehyde (2.03 g) was dissolved in dichloromethane (80 mL). To the solution was added dropwise a 1 mol/L solution of boron trichloride in dichloromethane (20 mL) under ice-cooling with stirring. The reaction mixture was stirred at room temperature for 24 hours. To the reaction mixture was added dropwise methanol (10 mL) under ice-cooling with stirring. After adding diluted hydrochloric acid, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.45 g).

後処理

  1. temperaturecooling
  2. stirringThe reaction mixture was stirred at room temperature for 24 hours
  3. temperaturecooling
  4. stirringwith stirring
  5. extractionthe reaction mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-673dbc83f4e7472797f5dce0eda61ea6
出典データセット
uspto-grants-2007_06
特許番号
US07230031B2

反応ノート

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