ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Hydrochloric Acid → 3-{2-[2-Benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]vinyl}furan

HRID 1766652
ノート
印刷プレビュー

反応式

HRID 1766652 の反応式
[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[C:3]1[O:7][CH:6]=[CH:5][CH:4]=1.[CH3:27][C:28](C)([O-])C.[K+].[CH2:33]([O:40][C:41]1[CH:48]=[CH:47][C:46]([O:49][C:50]2[C:58]([CH3:59])=[CH:57][C:56]([N+:60]([O-:62])=[O:61])=[C:55]3[C:51]=2[CH2:52][CH2:53][CH2:54]3)=[CH:45][C:42]=1C=O)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.Cl>O1CCCC1>[CH2:33]([O:40][C:41]1[CH:48]=[CH:47][C:46]([O:49][C:50]2[C:58]([CH3:59])=[CH:57][C:56]([N+:60]([O-:62])=[O:61])=[C:55]3[C:51]=2[CH2:52][CH2:53][CH2:54]3)=[CH:45][C:42]=1[CH:27]=[CH:28][C:5]1[CH:4]=[CH:3][O:7][CH:6]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 11418806Furfuryltriphenylphosphonium bromideHCID 23031138HCID 23031138、化合物HCID 23665647Potassium tert-butoxide

生成物 1

HCID 694253463-{2-[2-Benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)phenyl]vinyl}furan収率 73.5%

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

To a suspension of furfuryltriphenylphosphonium bromide (377 mg) in tetrahydrofuran (30 mL) was added potassium tert-butoxide (136 mg) at room temperature, and the mixture was stirred for 15 min. After adding 2-benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)benzaldehyde (377 mg), the mixture was stirred at room temperature for 6 hours. After adding dropwise diluted hydrochloric acid to make the mixture acidify fully, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate) to give the title compound (306 mg).

後処理

  1. stirringthe mixture was stirred at room temperature for 6 hours
  2. extractionthe reaction mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was removed under reduced pressure
  6. customThe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-3a268b5b5f91487391d9266c57426c06
出典データセット
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07230031B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート