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4-[2-Benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)benzylidene]tetrahydropyran → 4-(7-Amino-5-methylindan-4-yloxy)-2-(tetrahydropyran-4-yl methyl)phenol

HRID 1766653
ノート
印刷プレビュー

反応式

HRID 1766653 の反応式
C([O:8][C:9]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[C:31]([CH3:32])=[CH:30][C:29]([N+:33]([O-])=O)=[C:28]3[C:24]=2[CH2:25][CH2:26][CH2:27]3)=[CH:18][C:10]=1[CH:11]=[C:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)C1C=CC=CC=1.[H][H]>C(O)C.C(OCC)(=O)C.[Pd]>[NH2:33][C:29]1[CH:30]=[C:31]([CH3:32])[C:23]([O:22][C:19]2[CH:20]=[CH:21][C:9]([OH:8])=[C:10]([CH2:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:18]=2)=[C:24]2[C:28]=1[CH2:27][CH2:26][CH2:25]2
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 2

HCID 211105754-[2-Benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy)benzylidene]tetrahydropyranHCID 178418361HCID 178418361、化合物

生成物 1

HCID 230311814-(7-Amino-5-methylindan-4-yloxy)-2-(tetrahydropyran-4-yl methyl)phenol収率 80%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒
HCID 8857
Ethyl Acetate
溶媒

実験手順

4-[2-Benzyloxy-5-(5-methyl-7-nitroindan-4-yloxy) benzylidene]tetrahydropyran (230 mg) was dissolved in ethanol (10 mL) and ethyl acetate (2 mL). After adding 10% Pd/C (50 mg) under ice-cooling, the mixture was stirred at room temperature under an atmospheric pressure of hydrogen for 24 hours. The insoluble material was removed by filtration. The filtrate was evaporated under reduced pressure to dryness. The residue was purified by column chromatography on silica gel (eluent: exane/ethyl acetate) to give the title compound (138 mg).

後処理

  1. temperaturecooling
  2. customThe insoluble material was removed by filtration
  3. customThe filtrate was evaporated under reduced pressure to dryness
  4. customThe residue was purified by column chromatography on silica gel (eluent: exane/ethyl acetate)

出典と根拠

ORDレコード
ord-de6cd3345990483bb65b3dad9d721862
出典データセット
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07230031B2

反応ノート

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