Dimethylformamide → 2-[[Bis(allyloxy)phosphoryl]oxymethyl]-3-chlorobenzoyl chloride

反応式

[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](O)=[O:16])([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3].CN(C)C=O.C(Cl)(=O)C([Cl:31])=O>ClCCl>[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([Cl:31])=[O:16])([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3]

参加物

実験手順

A solution of 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-chlorobenzoic acid (936.1 mg, 2.7 mmol) obtained from Example 27-(4) in dichloromethane (15 ml) was cooled to 0° C., and then N,N-dimethylformamide (15 μl) and oxalyl chloride (1.71 g, 13.5 mmol) were added thereto. After the mixture was stirred at room temperature for 30 minutes, it was worked up according to a similar procedure to that described in Example 1-(12) to afford crude 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-chlorobenzoyl chloride.