HCID 23030469、化合物 → 4(3H)-Quinazolinone, 6-chloro-
反応式
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([O-])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[NH4+:12].[CH:13]([O-])([O-])OC>C(#N)C>[Cl:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:13][NH:12][C:7]2=[O:8]参加物
4
実験手順
In a 2-mL volume stainless steel pressure-resistant vessel were placed 340 mg (1.8 mmol) of ammonium 5-chloroanthranilate (prepared in the same manner as in Reference Example 3), 400 mg (3.6 mmol) of methyl orthoformate, and 1.5 mL of acetonitrile. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 303 mg (reaction yield: 93%) of 6-chloroquinazolin-4-one.
後処理
- customIn a 2-mL volume stainless steel pressure-resistant vessel were placed
出典と根拠
- ORDレコード
- ord-bcb0cfd10e4d43de9f743b8cab3cfcd8
- 出典データセット
- uspto-grants-2007_06
- 特許番号
- US07232903B2
反応ノート
読み込み中…