Hydrochloric Acid → [4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

HRID 1767881ノート

反応式

HRID 1767881 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[S:5][C:6]=1[CH2:7][C:8]#N.[OH-:20].[Na+].[OH2:22].Cl>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)[S:5][C:6]=1[CH2:7][C:8]([OH:22])=[O:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 23614503[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetonitrile

生成物 1

HCID 17972178[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

A mixture of [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetonitrile (8.86 g, 31 mmol), sodium hydroxide (12.5 g, 314 mmol), water (160 ml) and ethanol (160 ml) was stirred vigorously at 100° C. for 2.5 h. The reaction mixture was poured onto crushed ice and aqueous HCl and extracted three times with dichloromethane. The combined extracts were washed with water and brine, and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 9.5 g (quant.) of the title compound as light yellow solid.

後処理

  1. additionThe reaction mixture was poured
  2. extractionextracted three times with dichloromethane
  3. washThe combined extracts were washed with water and brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-bb43e20114094220b1245dd341010c87
出典データセット
uspto-grants-2007_06
特許番号
US07235572B2

反応ノート

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