Hexane → 2-(chloromethyl)-1H-thieno[3,4-d]imidazole
反応式
[S:1]1[CH:5]=[C:4]([NH2:6])[C:3]([NH2:7])=[CH:2]1.[Cl:8][CH2:9][C:10](OCC)(OCC)OCC.CCCCCC>C(COC)OC>[Cl:8][CH2:9][C:10]1[NH:7][C:3]2=[CH:2][S:1][CH:5]=[C:4]2[N:6]=1参加物
5
反応条件
- 温度
- 95 °C
実験手順
3,4-Thiophenediamine (0.5 g, Toronto Research Chemicals, Chemical Abstracts # 90069-81-1) and 2-chloro-1,1,1-triethoxyethane (0.9 g) were combined in dimethoxyethane (7 mL) in a sealed tube and heated at 95° C. for one hour. After allowing to cool to room temperature and stirring for 24 hours, the mixture was treated with hexane (10 mL) and filtered. The filter cake was dried under reduced pressure to provide the title compound. MS (DCI/NH3) m/z 173 (M+H)+.
後処理
- temperatureto cool to room temperature
- filtrationfiltered
- customThe filter cake was dried under reduced pressure
出典と根拠
- ORDレコード
- ord-f00ae53982f64b8bb9e38a03c8ee3a72
- 出典データセット
- uspto-grants-2007_06
- 特許番号
- US07235661B2
反応ノート
読み込み中…