Benzoyl Peroxide → 1-(1-Bromoethyl)-4-(trimethylsilyl)benzene

HRID 1768561ノート

反応式

HRID 1768561 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:12])([CH3:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:2].[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:13][CH:1]([C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:10])([CH3:12])[CH3:11])=[CH:5][CH:4]=1)[CH3:2]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 280168(4-Ethylphenyl)trimethylsilane

生成物 1

HCID 189488471-(1-Bromoethyl)-4-(trimethylsilyl)benzene収率 91%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

The product of Step A (59 g, 0.33 mole) was dissolved in carbon tetrachloride (700 mL). To this solution was added N-bromosuccinimide (59 g, 0.33 mole) and benzoyl peroxide (ca. 200 rag) in one portion. The reaction mixture was heated to reflux for 2.5 hours while being irradiated with a 275 watt sunlamp. After cooling, the solid succinimide was removed by filtration and the filtrate was washed with saturated aqueous NaHSO3. Drying (MgSO4) and concentration gave an oil (77 g, 91% yield) which was used in the next step without further purification.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 2.5 hours
  3. customwhile being irradiated with a 275 watt sunlamp
  4. temperatureAfter cooling
  5. customthe solid succinimide was removed by filtration
  6. washthe filtrate was washed with saturated aqueous NaHSO3
  7. customDrying
  8. concentration(MgSO4) and concentration

出典と根拠

ORDレコード
ord-e41c25baefde4f14adf9090dc61d831a
出典データセット
uspto-grants-1995_01
特許番号
US05378708

反応ノート

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