Hydrazine hydrate (1:1) → 3-(2-Pyridyl)propanoic acid, hydrazide
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]([O:11]CC)=O.O.[NH2:15][NH2:16]>CCO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]([NH:15][NH2:16])=[O:11]参加物
4
実験手順
To a stirring 5 mL EtOH solution of 0.58 g (3.2 mmol) of ethyl 3-(2-pyridinyl)propanoate (4), prepared as described above in Example 4, was added 0.32 g (6.5 mmol) of hydrazine hydrate. The reaction was heated at reflux for three weeks. Although the reaction was still incomplete, the solvent was removed under vacuum. The resulting gum was triturated with diethyl ether (Et2O). The product remained a gum. The yield of 3-(2-pyridyl)propanoic acid, hydrazide (5) was 0.22 g (42%). This product was used immediately in the manner described in Example 6 below.
後処理
- temperatureThe reaction was heated
- temperatureat reflux for three weeks
- customthe solvent was removed under vacuum
- customThe resulting gum was triturated with diethyl ether (Et2O)
出典と根拠
- ORDレコード
- ord-86e4953eb0aa43dcba89d42b69a4c7d9
- 出典データセット
- uspto-grants-1995_01
- 特許番号
- US05378840
反応ノート
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