Hydrogen Bromide → 4-(3,4-Dihydroxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide

HRID 1768808ノート

反応式

HRID 1768808 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH:11]2[C:20]3[C:15](=[C:16]([CH3:21])[CH:17]=[CH:18][CH:19]=3)[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:22]>>[BrH:22].[OH:2][C:3]1[CH:4]=[C:5]([CH:11]2[C:20]3[C:15](=[C:16]([CH3:21])[CH:17]=[CH:18][CH:19]=3)[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[OH:9]

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 105170974-(3,4-Dimethoxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 147195524-(3,4-Dihydroxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide

実験手順

To 420 mg of 4-(3,4-dimethoxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline, was added 48% hydrobromic acid, and the mixture was heated under reflux for 3 hours. After about 10 minutes, the crystals becomes to be separated out. The reaction mixture was cooled, and the crystals were collected by filtration, giving 420 mg of 4-(3,4-dihydroxyphenyl)-8-methyl-1,2,3,4-tetrahydroisoquinoline hydrobromide.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customto be separated out
  4. temperatureThe reaction mixture was cooled
  5. filtrationthe crystals were collected by filtration

出典と根拠

ORDレコード
ord-3b39e02285524f6184a9da7e294c0d3f
出典データセット
uspto-grants-1995_01
特許番号
US05378849

反応ノート

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