Triethylamine → 1-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine

HRID 1768945

反応式

HRID 1768945 の反応式
[C:1]12([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C(N(CC)CC)C.[Cl:24][C:25]1[C:26](=[O:32])[NH:27][N:28]=[CH:29][C:30]=1Cl>C(O)C>[C:1]12([N:11]3[CH2:16][CH2:15][N:14]([C:30]4[CH:29]=[N:28][NH:27][C:26](=[O:32])[C:25]=4[Cl:24])[CH2:13][CH2:12]3)[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2

参加物

5

反応物 3

HCID 8471TriethylamineHCID 35373Piperazine, 1-(1-adamantyl)-HCID 732474,5-Dichloro-3-hydroxypyridazine

生成物 1

HCID 189463041-(1-Adamantyl)-4-(4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl)piperazine収率 73.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1-(1-adamantyl)piperazine (2.2 g, 10 mmol), triethylamine (1.36 ml, 10 mmol) and 4,5-dichloro-3-oxo-2,3-dihydropyridazine (1.65 g, 10 mmol) in ethanol (25 ml) was heated under reflux for 5 hours. After cooling the precipitated solids were collected, washed with ethanol and dried to afford 2.57 g of the title compound, yield: 73.6%, mp. 292°-294° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling the precipitated solids
  4. customwere collected
  5. washwashed with ethanol
  6. customdried

出典と根拠

ORDレコード
ord-983c00e751b44387b3912056b5a06470
出典データセット
uspto-grants-1995_01
特許番号
US05380724

関連ノート

読み込み中…