Water → 2-chloro-N-[4-(cyanomethyl)phenyl]acetamide

HRID 1768956ノート

反応式

HRID 1768956 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[NH2:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1.O>CC(N(C)C)=O>[Cl:1][CH2:2][C:3]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([CH2:11][C:12]#[N:13])=[CH:9][CH:8]=1)=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 770004-Aminophenylacetonitrile

生成物 1

HCID 49623062-chloro-N-[4-(cyanomethyl)phenyl]acetamide収率 87.8%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

2-Chloroacetyl chloride (3.3 ml, 5.0 g, 44 mmol) was added dropwise at 10°-15° C. to a solution of 4-aminobenzylcyanide (5.3 g, 40 mmol) in dimethyl acetamide (20 ml) and the mixture was stirred at room temperature for one hour. After pouring into water the precipitate was collected, washed with water and dried over P2O5 under reduced pressure to give the title compound (7.33 g) as nearly colorless crystals, yield: 87.8%, mp 124°-125° C.

後処理

  1. customwas collected
  2. washwashed with water
  3. dry with materialdried over P2O5 under reduced pressure

出典と根拠

ORDレコード
ord-78165c549a5d413e814d61de0f271d79
出典データセット
uspto-grants-1995_01
特許番号
US05380724

反応ノート

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