2-Amino-6-methylbenzothiazole → 4-Bromo-6-methyl-1,3-benzothiazol-2-amine

HRID 1769019

反応式

HRID 1769019 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:12]Br>C(Cl)(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([Br:12])[C:5]=2[N:6]=1

参加物

4

反応物 2

HCID 173352-Amino-6-methylbenzothiazoleHCID 24408Bromine

生成物 1

HCID 32786344-Bromo-6-methyl-1,3-benzothiazol-2-amine収率 92%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

16.4 g of 2-amino-6-methylbenzothiazole was dissolved in 500 ml of chloroform. To this solution was added dropwise 16.0 g of bromine dissolved in 10 ml of chloroform at room temperature. The reaction mixture was stirred for 2 hours and then washed once with 10% aqueous sodium hydroxide solution and water, respectively. The organic layer was separated, dried with anhydrous sodium sulfate and then evaporated to obtain the title compound in the yield of 92%.

後処理

  1. washwashed once with 10% aqueous sodium hydroxide solution and water
  2. customThe organic layer was separated
  3. dry with materialdried with anhydrous sodium sulfate
  4. customevaporated

出典と根拠

ORDレコード
ord-93014e4c4e5e44beba6c9c3b7bc461cc
出典データセット
uspto-grants-1995_01
特許番号
US05380735

関連ノート

読み込み中…