Trifluoroacetic acid → HCID 15228076、化合物

HRID 1769031ノート

反応式

HRID 1769031 の反応式
[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]1)=[O:16].FC(F)(F)C(O)=O.C(=O)([O-])O.[Na+]>>[CH3:1][CH2:2][O:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[C:15]([CH:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1)=[O:16]

参加物

4

反応物 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 540144471-[[(2-Ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl)methanone

生成物 1

HCID 15228076HCID 15228076、化合物

実験手順

Mix 1-[[(2-ethoxy)ethyl]-1H-benzimidazol-2-yl][1-(t-butyloxycarbonyl)-4-piperidinyl]methanone (10.07 g, 26.67 mmol) and trifluoroacetic acid (75 mL). Stir at room temperature until the reaction is complete. Pour onto water and carefully neutralize with solid sodium hydrogen carbonate. Extract into ethyl acetate (2×), wash with brine and dry (MgSO4). Evaporate the solvent in vacuo and purify by chromatography to give the title compound.

後処理

  1. additionPour onto water
  2. extractionExtract into ethyl acetate (2×)
  3. washwash with brine
  4. dry with materialdry (MgSO4)
  5. customEvaporate the solvent in vacuo
  6. custompurify by chromatography

出典と根拠

ORDレコード
ord-c2a19692b3094a1c9b0b889db26201ea
出典データセット
uspto-grants-1995_01
特許番号
US05380731

反応ノート

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