(Methoxymethyl)triphenylphosphonium bromide → 1-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

HRID 1769425ノート

反応式

HRID 1769425 の反応式
C([Li])CCC.[Br-].[CH3:7][O:8][CH2:9][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:29][CH:30]([O:34][C:35]1[CH:42]=[CH:41][C:38]([CH:39]=O)=[CH:37][CH:36]=1)[CH2:31][CH2:32][CH3:33]>CCCCCC.O1CCCC1>[CH3:7][O:8][CH:9]=[CH:39][C:38]1[CH:41]=[CH:42][C:35]([O:34][CH:30]([CH3:29])[CH2:31][CH2:32][CH3:33])=[CH:36][CH:37]=1

参加物

6

反応物 3

HCID 2773654(Methoxymethyl)triphenylphosphonium bromideHCID 199306244-(1-Methylbutyloxy)benzaldehydeHCID 178418339Butyllithium

生成物 1

HCID 537267651-(2-Methoxyethenyl)-4-(1-methylbutyloxy)benzene

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 8058Hexane溶媒

実験手順

A solution containing butyllithium dissolved in hexane was added to a solution containing 120 g of methoxymethyltriphenylphosphonium bromide dissolved in tetrahydrofuran (THF), in an atmosphere of argon, and the mixture was stirred for one hour at room temperature. A solution of the compound (30) dissolved in THF was added thereto and stirring was continued for two hours. The reaction solution was washed with water, was dried over magnesium sulfate, and was then concentrated. The residue was purified by column chromatography to obtain 1-(2-methoxyethenyl)-4-(1-methylbutyloxy)benzene (31).

後処理

  1. additionwas added to a solution
  2. additionwas added
  3. stirringstirring
  4. waitwas continued for two hours
  5. washThe reaction solution was washed with water
  6. dry with materialwas dried over magnesium sulfate
  7. concentrationwas then concentrated
  8. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-8d833bd498db432498c9cbaaf963bb50
出典データセット
uspto-grants-1995_01
特許番号
US05380915

反応ノート

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