Benzyl Alcohol → Benzyloxycarbonylpropyleneurea

反応式

[O:1]([C:8]([CH2:10][CH:11]([NH:13][C:14]([NH2:16])=[O:15])[CH3:12])=O)C1C=CC=CC=1.[CH2:17]([OH:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C([O-])(=O)CCCCCCCCCCC.C([O-])(=O)CCCCCCCCCCC.C([Sn+2]CCCC)CCC.CN(C1C=CC=CN=1)C>>[CH2:17]([O:24][C:8]([CH2:10][CH:11]([NH:13][C:14]([NH2:16])=[O:15])[CH3:12])=[O:1])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

反応物 4

HCID 244Benzyl Alcohol

HCID 218852-Dimethylaminopyridine

HCID 9809426Di-n-butyldilauryltin

HCID 67742160Phenoxycarbonylpropyleneurea

生成物 1

HCID 67742170Benzyloxycarbonylpropyleneurea

反応条件

温度: 100 °C

実験手順

A mixture of phenoxycarbonylpropyleneurea of 1.0 g (4.5 mmol), benzyl alcohol of 2.4 g (22.2 mmol), dibutyltin dilaurate of 20 mg (0.6 wt %) and dimethylaminopyridine of 20 mg (0.6 wt %) was heated for 3 hours at 100° C. with stirring. After confirming the completion of the reaction by the thin layer chromatograpy, the reaction product was concentrated and the resulting crude substance was separated by the chromatography to obtain the aimed substance of 600 mg (56.4%).