Aniline → HCID 15022346、化合物

HRID 1770320ノート

反応式

HRID 1770320 の反応式
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

参加物

5

反応物 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

生成物 1

HCID 15022346HCID 15022346、化合物

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 312751,4-Dioxane溶媒

実験手順

4-Chlorothiophene-3-carbonyl chloride (13.5 g, 0.075 mol) are dissolved in 30 ml of dioxane and the solution is added dropwise at room temperature to a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). Stirring is carried out for 12 hours at room temperature, after which the mixture is evaporated to dryness and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and evaporated to dryness. Yield: 16.7 g, 94%; mp. 119° to 121° C.

後処理

  1. customafter which the mixture is evaporated to dryness
  2. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  3. customdried
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-d6e97c5bb61e42c1a2ac2eb24abb4254
出典データセット
uspto-grants-1995_01
特許番号
US05386036

反応ノート

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