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HRID 1770620作成日：2026年10月27日

5-(chloromethyl)-1,3-dimethyl-1H-pyrazole → 1-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione

https://huagongshe.com/reaction/1770620

反応式

関与物質

役割名称HCID仕込み量
反応物5-(chloromethyl)-1,3-dimethyl-1H-pyrazoleHCID 4961270—
反応物3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dioneHCID 59524388—
生成物1-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dioneHCID 53373958—

反応手順

Prepared as in Example 12-16 from 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-5,5-dimethylimidazolidine-2,4-dione (Example 12-16a) and 5-(chloromethyl)-1,3-dimethyl-1H-pyrazole. MS 412 (MH+). The title compound was shown to inhibit hT2R08 bitter receptor and had an 1050 of 0.23 μM.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09247759B2
出典データセットuspto-grants-2016_02
ORD IDord-660c4cb76b444b9181d39aaa2392c08e
出典メモuspto-grants-2016_02