4-Nitrophenol → 4-Nitrophenoxyacetonitrile

HRID 1770848ノート

反応式

HRID 1770848 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].Br[CH2:12][C:13]#[N:14].C([O-])([O-])=O.[K+].[K+]>CC(C)=O.O>[C:13]([CH2:12][O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)#[N:14]

参加物

6

反応物 3

HCID 9804-NitrophenolHCID 11430Potassium CarbonateHCID 11534Bromoacetonitrile

生成物 1

HCID 1418544-Nitrophenoxyacetonitrile

試薬・触媒・溶媒 2

HCID 180Acetone溶媒2 回HCID 962Water溶媒

実験手順

4-Nitrophenol (10 g), bromoacetonitrile (6 mL) and K2CO3 (15 g) were suspended in acetone (100 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and acetone was removed under reduced pressure. The light-yellow precipitate was collected by filtration, washed with water and dried to give O-cyanomethyl-4-nitrophenol.

後処理

  1. customwas removed under reduced pressure
  2. filtrationThe light-yellow precipitate was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-1f231dc690f044099d2edc7e17bb208e
出典データセット
uspto-grants-2016_02
特許番号
US09248190B2

反応ノート

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