2-Methyl-2-(4-nitrophenoxy)propanamide → 2-(4-Aminophenoxy)-2-methylpropanamide

HRID 1770854ノート

反応式

HRID 1770854 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([NH2:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]([CH3:14])([CH3:13])[C:10]([NH2:12])=[O:11])=[CH:15][CH:16]=1

参加物

4

反応物 1

HCID 123215222-Methyl-2-(4-nitrophenoxy)propanamide

生成物 1

HCID 575629072-(4-Aminophenoxy)-2-methylpropanamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-(4-Nitrophenoxy)-2-methylpropanamide was dissolved in methanol (50 mL) and to the solution was added 10% Pd—C (500 mg). The reaction mixture was reacted under hydrogen atmosphere (˜40 psi) for 1 h. The catalyst was filtered off over celite. The filtrate was evaporated to give 2-(4-aminophenoxy)-2-methylpropanamide as a white solid.

後処理

  1. customThe reaction mixture was reacted under hydrogen atmosphere (˜40 psi) for 1 h
  2. filtrationThe catalyst was filtered off over celite
  3. customThe filtrate was evaporated

出典と根拠

ORDレコード
ord-8df75659d1b2463eb7f368e9cf9cff3f
出典データセット
uspto-grants-2016_02
特許番号
US09248190B2

反応ノート

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