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Methyl Acrylate → 6'-Isobutoxyspiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acrylate | HCID 7294 | — |
| 反応物 | 6-Isobutoxyindan-1-one | HCID 44072847 | — |
| 反応物 | 6'-(3-Fluoropropoxy)spiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione | HCID 67979557 | — |
| 生成物 | 6'-Isobutoxyspiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione | HCID 67979319 | 72% |
反応手順
The title compound (3.02 g, 72% yield) was prepared using the method described for Intermediate 63 starting from 6-isobutoxy-2,3-dihydro-1H-inden-1-one (Intermediate 66, 3.0 g, 14.7 mmol) and methyl acrylate (2.92 mL, 32.3 mmol): 1H NMR (400 MHz, CDCl3) δ ppm 1.04 (m, 8H) 1.86 (m, 2H) 2.11 (dt, 1H) 2.21 (m, 2H) 2.47 (m, 3H) 2.70 (m, 2H) 3.15 (s, 2H) 3.76 (m, 3H) 7.20 (m, 1H) 7.25 (m, 1H) 7.38 (d, 1H); MS (ES+) m/z 287 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09248129B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-df894d5eff98437c9550230720db36b7 |
| 出典メモ | uspto-grants-2016_02 |