(alphaR,betaR)-beta-ethyl-N,N,alpha-trimethyl-3-(phenylmethoxy)benzenepropanamide → (alphaR,betaR)-beta-ethyl-3-hydroxy-N,N,alpha-trimethylbenzenepropanamide
反応式
[CH2:1]([C@@H:3]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17]CC2C=CC=CC=2)[CH:12]=1)[C@@H:4]([CH3:10])[C:5]([N:7]([CH3:9])[CH3:8])=[O:6])[CH3:2]>CO.[Pd]>[CH2:1]([C@@H:3]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=1)[C@@H:4]([CH3:10])[C:5]([N:7]([CH3:8])[CH3:9])=[O:6])[CH3:2]参加物
4
実験手順
The product of Example 5 (3.0 g, 9 mmol) was dissolved in methanol, 5% Pd—C (300 mg) was added therein, after it was purged with hydrogen for three times, the reaction was carried out with stirring at room temperature for 1 hr. Then the reaction solution was filtered to remove Pd—C, the residue was washed with methanol for 3 times, and the organic phases are combined and concentrated to give the target 2.0 g, yield: 95%. 1HNMR (300 MHz, CDCl3): δ 7.2 (1H, m), 6.7-6.8 (3H, m), 2.8-2.9 (1H, m), 2.7-2.8 (1H, m), 2.6 (3H, s), 2.5 (3H, s), 1.8-1.9 (1H, m), 1.4-1.6 (1H, m), 1.1 (3H, d, J=6.2), 0.8 (3H, t, J=6.8, 14.1). ESI-MS: 236.4 (M+H).