Benzyl Alcohol → Benzyl 2-bromo-2,2-difluoroacetate

HRID 1771028ノート

反応式

HRID 1771028 の反応式
[Br:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8](O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1CCCCC1>[Br:1][C:2]([F:7])([F:6])[C:3]([O:5][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:4]

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 521998p-Toluenesulfonic acid monohydrateHCID 27732822-Bromo-2,2-difluoroacetic acid

生成物 1

HCID 10378165Benzyl 2-bromo-2,2-difluoroacetate

試薬・触媒・溶媒 1

HCID 8078Cyclohexane溶媒

実験手順

This compound was prepared according to Example 2a from bromodifluoroacetic acid (9.82 g; 68.7 mmol), benzyl alcohol (7.0 g; 65 mmol), and p-toluenesulphonic acid monohydrate (50 mg) in cyclohexane (120 mL). The crude product obtained after evaporation was used as is without any further workup in 3b.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-73f25d56bc8441348449fcc0b66adb7e
出典データセット
uspto-grants-2016_02
特許番号
US09249086B2

反応ノート

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