Hydrazine hydrate (1:1) → 2-(1H-1,3-benzodiazol-2-yl)acetohydrazide

HRID 1771120ノート

反応式

HRID 1771120 の反応式
C([O:3][C:4](=O)[CH2:5][C:6]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]=1)C.O.[NH2:17][NH2:18]>C(O)C>[NH:7]1[C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=[C:6]1[CH2:5][C:4]([NH:17][NH2:18])=[O:3]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 308071ethyl 2-(1H-1,3-benzodiazol-2-yl)acetate

生成物 1

HCID 6806472-(1H-1,3-benzodiazol-2-yl)acetohydrazide収率 76%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

15 g 1H-benzo[d]imidazole-2-acetic acid ethyl ester (0.074 mol), 100 mL anhydrous ethyl alcohol and 37 mL of 80% hydrazine hydrate were added to a three-necked bottle and reacted under reflux for 4 hours. A white solid was isolated. After sucking filtration, the filter cake was washed with ethanol. After drying, 10.7 g white solid was obtained. Yield: 76%, MS: 191(M+1).

後処理

  1. customreacted
  2. temperatureunder reflux for 4 hours
  3. customA white solid was isolated
  4. filtrationfiltration
  5. washthe filter cake was washed with ethanol
  6. customAfter drying

出典と根拠

ORDレコード
ord-d7c5dd9ae5d34509b520c722d18c00e2
出典データセット
uspto-grants-2016_02
特許番号
US09249106B2

反応ノート

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