1-Bromo-2-ethylbenzene → HCID 93510923、化合物
反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH3:9].[Li][CH2:11][CH2:12][CH2:13][CH3:14].[O:15]1[C@H](CC)C1>C1COCC1>[CH2:13]([C:12]1[CH:11]=[CH:4][CH:5]=[CH:6][C:7]=1[C@H:2]([OH:15])[CH2:3][CH2:8][CH3:9])[CH3:14]参加物
5
反応条件
- 温度
- -78 °C
実験手順
The 1-bromo-2-ethylbenzene (2.0 g) was dissolved in dry THF and the mixture was cooled to −78° C. 1.6 M n-BuLi (20.26 ml) was slowly added to the reaction mixture and then the mixture was stirred at −78° C. After 1 h (R)-(+)-1,2-epoxybutane (1.1 g) was added in 10 ml of THF. The reaction mixture was allowed to warm to ambient temperature and then stirred over night. The reaction was quenched with ice-water and product extracted in heptanes, and finally purified by using the separation method E yielding the title compound (1.1 g).
後処理
- temperatureto warm to ambient temperature
- stirringstirred over night
- customThe reaction was quenched with ice-water and product
- extractionextracted in heptanes
- customfinally purified
- customthe separation method E
出典と根拠
- ORDレコード
- ord-01c265e2467949fd9ee20c95a63f0c7b
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249127B2
反応ノート
読み込み中…