4-(4-Methoxynaphthalen-1-yloxy)-1-nitrobenzene → 4-(4-Methoxy-naphthalen-1-yloxy)aniline

HRID 17716ノート

反応式

HRID 17716 の反応式
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[CH:5][CH:4]=1>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][C:14]2[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 669773744-(4-Methoxynaphthalen-1-yloxy)-1-nitrobenzene

生成物 1

HCID 669774504-(4-Methoxy-naphthalen-1-yloxy)aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

The nitro intermediate (10 mmol) obtained above was dissolved in EtOAc (50 mL) and hydrogenated in the presence of 10% Pd/C (360 mg) until completion according to General Procedure H, as indicated by TLC or HPLC. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(4-methoxy-naphthalen-1-yloxy)aniline, which was used directly for further transformation without further purification.

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

出典と根拠

ORDレコード
ord-8fe4de66f704498f9920a77fee9b4f5c
出典データセット
uspto-grants-2010_06
特許番号
US07737285B2

反応ノート

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