Methyl iodide → 1,3-Dichloro-4-methoxy-2-nitrobenzene
反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[CH:5]=[CH:4][C:3]=1[OH:12].[C:13]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Cl:11][C:6]1[CH:5]=[CH:4][C:3]([O:12][CH3:13])=[C:2]([Cl:1])[C:7]=1[N+:8]([O-:10])=[O:9]参加物
5
実験手順
To a solution of 2,4-dichloro-3-nitro-phenol (600 mg, 2.9 mmol, 1.0 eq) in acetone (30 mL), was added K2CO3 (1.2 g, 8.7 mmol, 3.0 eq) and the solution was stirred at room temperature for 30 min. Methyl iodide (1.2 g, 8.7 mmol, 3.0 eq) was added and the reaction was stirred at room temperature overnight. The reaction was filtered to remove the inorganic salts and the organic phase was evaporated in vacuo to give the title compound (550 mg, 86%).
後処理
- stirringthe reaction was stirred at room temperature overnight
- filtrationThe reaction was filtered
- customto remove the inorganic salts
- customthe organic phase was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-7074dac009fa46b0a988e9fe93fd5563
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249085B2
反応ノート
読み込み中…