N,N-Dimethylaniline → 3,6-Dimethylpyrazin-2-amine

HRID 1771995

反応式

HRID 1771995 の反応式
[CH3:1][C:2]1[CH:7]=[N:6][C:5]([CH3:8])=[CH:4][N:3]=1.C[N:10](C)C1C=CC=CC=1>>[CH3:8][C:5]1[C:4]([NH2:10])=[N:3][C:2]([CH3:1])=[CH:7][N:6]=1

参加物

3

反応物 2

HCID 949N,N-DimethylanilineHCID 312522,5-Dimethylpyrazine

生成物 1

HCID 132615003,6-Dimethylpyrazin-2-amine収率 10%

反応条件

温度
170 °C

実験手順

A mixture of 2,5-dimethylpyrazine (14 g, 0.13 mol) in N,N-dimethylaniline (50 mL) was heated to 170° C. and NaNH2 (22 g, 0.56 mol) was added in portions. The reaction mixture was stirred at 170° C. for 1 h, and the solvent was removed. The product was purified by silica gel column chromatography to give 3,6-dimethylpyrazin-2-amine as a brown solid (1.6 g, yield 10%). ESI MS: m/z 124 [M+H]+.

後処理

  1. customthe solvent was removed
  2. customThe product was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-9de2d6ac326c466ba5d1bcbc64d40b01
出典データセット
uspto-grants-2016_02
特許番号
US09249162B2

関連ノート

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