Hydrazine hydrate (1:1) → 8-Amino-7-(methylamino)quinoline
反応式
[CH3:1][NH:2][C:3]1[C:12]([N+:13]([O-])=O)=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.O.NN>CO.[Ni]>[CH3:1][NH:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1参加物
5
実験手順
To a solution of N-methyl-8-nitroquinolin-7-amine (1.6 g, 7.9 mmol) in MeOH (25 mL) was added hydrazine hydrate (2.25 g, 455 mmol) and Raney Ni (8 drops). The mixture was stirred at room temperature for 20 minutes. The catalyst was removed by filtration and the filtrate was concentrated to give N7-methylquinoline-7,8-diamine as a yellow solid (1.2 g, yield 80%). ESI MS: m/z 174 [M+H]+.
後処理
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-2cab1ecb9ed145beae261eae632eb5f5
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249162B2
反応ノート
読み込み中…