Acetonitrile → 4-Methyl-3-carbonyl valeronitrile
反応式
[C:1](OC)(=O)[CH:2]([CH3:4])C.[O-:8][CH2:9][CH3:10].[Na+].[C:12](#[N:14])[CH3:13]>CO>[CH3:1][CH:2]([CH3:4])[C:10](=[C:9]=[O:8])[CH2:13][C:12]#[N:14]参加物
5
実験手順
To a 1 L of round bottom flask were added methyl isobutyrate (100 g, 0.98 mol), sodium ethoxide (66.63 g, 0.98 mol), acetonitrile (53.9 g, 0.98 mol) and 300 ml of methanol at room temperature. The resultant mixture was slowly warmed and refluxed. The reaction was kept for 6 hr. The reaction was stopped and cooled to room temperature. The solvent was rotary-evaporated. The product was distilled under reduced pressure (12 mmHg) to collect at 102-104° C. 56.2 g of the pure title compound.
後処理
- temperaturerefluxed
- customThe solvent was rotary-evaporated
- distillationThe product was distilled under reduced pressure (12 mmHg)
- customto collect at 102-104° C
出典と根拠
- ORDレコード
- ord-e8b5ee671ec84da7bdcf9070e0f4e98a
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09249172B2
反応ノート
読み込み中…