N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide → 2-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide

HRID 1772879ノート

反応式

HRID 1772879 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([NH:9][S:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-])=O)(=[O:12])=[O:11])=[CH:5][C:4]=1[CH3:22]>[Pd].C(O)C.CCOC(C)=O>[NH2:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[S:10]([NH:9][C:6]1[CH:7]=[N:8][C:3]([O:2][CH3:1])=[C:4]([CH3:22])[CH:5]=1)(=[O:11])=[O:12]

参加物

4

反応物 1

HCID 90022532N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide

生成物 1

HCID 900307172-amino-N-(6-methoxy-5-methylpyridin-3-yl)benzenesulfonamide収率 106.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584252Ethanol ethylacetate溶媒

実験手順

A mixture of N-(6-methoxy-5-methylpyridin-3-yl)-2-nitrobenzenesulfonamide (2.69 g, 8.32 mmol) and 10% palladium on charcoal (1.35 g) in ethanol/EtOAc (1:1, 100 mL total reaction volume) was stirred at rt under an atmosphere of H2 for approximately 2.5 h. Filtration and concentration in vacuo yielded the crude title compound (2.60 g).

後処理

  1. filtrationFiltration and concentration in vacuo

出典と根拠

ORDレコード
ord-886338baa49241c6a370f08fa640ef18
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

反応ノート

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