Triethylamine → 4-[(3,5-Difluoropyridin-2-yl)methyl]-2-(3,4-dimethoxyphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

HRID 1772967

反応式

HRID 1772967 の反応式
[F:1][C:2]1[C:3]([CH2:9][NH2:10])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.C(N(CC)CC)C.FC1C=C(OC)C=C(F)C=1CN1[C:39]2[N:40]=[CH:41][CH:42]=[CH:43][C:38]=2[S:37](=[O:45])(=[O:44])[N:36]([C:46]2[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[C:48]([O:54][CH3:55])[CH:47]=2)[C:35]1=[O:56]>>[F:1][C:2]1[C:3]([CH2:9][N:10]2[C:39]3[N:40]=[CH:41][CH:42]=[CH:43][C:38]=3[S:37](=[O:45])(=[O:44])[N:36]([C:46]3[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[C:48]([O:54][CH3:55])[CH:47]=3)[C:35]2=[O:56])=[N:4][CH:5]=[C:6]([F:8])[CH:7]=1

参加物

5

反応物 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 21069854(3,5-Difluoropyridin-2-YL)methanamineHCID 900546714-(2,6-difluoro-4-methoxybenzyl)-2-(3,4-dimethoxyphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3 (4H)-one 1,1-dioxide

生成物 1

HCID 727218914-[(3,5-Difluoropyridin-2-yl)methyl]-2-(3,4-dimethoxyphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide

実験手順

The title compound (16 mg, 0.03 mmol) was prepared in two steps from (IntC1) (82 mg, 0.25 mmol) and (3,5-difluoropyridin-2-yl)methanamine (108 mg, 0.75 mmol); followed by 1,1′-carbonyldiimidazole (65 mg, 0.4 mmol) and triethylamine (28 uL, 0.2 mmol) using the methods of (95).

出典と根拠

ORDレコード
ord-1b03a60f2a4249468506fdcf0ee72b44
出典データセット
uspto-grants-2016_02
特許番号
US09249160B2

関連ノート

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