Sodium Carbonate → Oseltamivir

HRID 1773014

反応式

HRID 1773014 の反応式
[CH3:1][CH2:2][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:4][CH3:5].P(=O)([O-])[O-].C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[CH3:5][CH2:4][CH:3]([O:6][C@H:7]1[C@H:12]([NH:13][C:14]([CH3:16])=[O:15])[C@@H:11]([NH2:17])[CH2:10][C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:8]1)[CH2:2][CH3:1]

参加物

4

反応物 2

HCID 10340Sodium CarbonateHCID 178469146HCID 178469146、化合物

生成物 1

HCID 65028Oseltamivir

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A stirred solution of oseltamivir phosphonate (100 mg) in 50 mL DCM was treated with 50 ml aqueous Na2CO3 (60 mg). The white solution was stirred over a period of 45 minutes at room temperature. The combined aqueous and organic layers were extracted with dichloromethane (100 mL) and the organic phase was dried over Na2SO4. The combined organic phases were evaporated in a rotary evaporator to yield the product oseltamivir as a liquid, which was used without further purification in the next step. Oseltamivir amine was

後処理

  1. extractionThe combined aqueous and organic layers were extracted with dichloromethane (100 mL)
  2. dry with materialthe organic phase was dried over Na2SO4
  3. customThe combined organic phases were evaporated in a rotary evaporator

出典と根拠

ORDレコード
ord-6b928a25700d47eca71c698550f86623
出典データセット
uspto-grants-2016_02
特許番号
US09250238B2

関連ノート

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