Hydrochloric Acid → 3-Methyl-3-phenylbutan-2-one

HRID 1773908ノート

反応式

HRID 1773908 の反応式
CON(C)[C:4](=[O:14])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].[Li]C.[CH3:18]COCC.Cl>C1COCC1>[CH3:6][C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[C:4](=[O:14])[CH3:18]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 59788661N-Methoxy-N-methyl-2-phenyl-isobutyramideHCID 178418348HCID 178418348、化合物

生成物 1

HCID 2854623-Methyl-3-phenylbutan-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of N-methoxy-N-methyl-2-phenyl-isobutyramide (example 207E) (16 g, 77.2 mmoles) in THF (300 mL) cooled at −50° C. is added dropwise a 1.6M solution of MeLi in Et2O (80 mL, 131.2 mmoles). The reaction mixture is allowed to reach 0° C. and 1N HCl (130 mL, 130 mmoles) is added. The aqueous phase is extracted with Et2O. The organic phase is washed with brine, dried over MgSO4, filtered and the solvent is removed under reduced pressure to give 3-methyl-3-phenyl-butan-2-one.

後処理

  1. customto reach 0° C.
  2. extractionThe aqueous phase is extracted with Et2O
  3. washThe organic phase is washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customthe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-df5282149dc0482aa6d17b1b3e2c6c34
出典データセット
uspto-grants-2016_02
特許番号
US09255101B2

反応ノート

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