Hydrochloric Acid → 3-Bromo-4-(trifluoromethoxy)benzoic acid

HRID 1773952ノート

反応式

HRID 1773952 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12])[CH:5]=[O:6].[OH:15]O.Cl>CO.[OH-].[Na+]>[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:12])([F:13])[F:14])[C:5]([OH:15])=[O:6]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 131504163-Bromo-4-(trifluoromethoxy)benzaldehyde

生成物 1

HCID 202740913-Bromo-4-(trifluoromethoxy)benzoic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

To an ice-cooled solution of 3-bromo-4-(trifluoromethoxy)benzaldehyde (3.00 g, 11.2 mmol, 1 eq.) in MeOH (14 mL), a solution of hydrogen peroxide (30% wt solution in water, 14 mL, 11.2 mmol, 1 eq.) in 15% aq. NaOH soln. (14 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 1 hour and further at r.t. for 18 hours. The reaction mixture was acidified by addition of conc. HCl. The suspension was filtered off and the filter cake was rinsed with H2O. The resulting white solid was dried under h.v. to give the title compound. The product was used without further purification.

後処理

  1. addition(14 mL) was added dropwise
  2. filtrationThe suspension was filtered off
  3. washthe filter cake was rinsed with H2O
  4. customThe resulting white solid was dried under h.v

出典と根拠

ORDレコード
ord-2f3609b69d7549179c6830933b59da0a
出典データセット
uspto-grants-2016_02
特許番号
US09255090B2

反応ノート

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