Hydrochloric Acid → HCID 15882750、化合物
反応式
Br[CH2:2][C:3]1[C:4]([O:6][C:7](=[O:10])[C:8]=1[CH3:9])=[O:5].[OH-:11].[Na+].Cl.[Cl-].[Na+]>CCCCCC.C(OCC)(=O)C>[OH:11][CH2:2][C:3]1[C:4]([O:6][C:7](=[O:10])[C:8]=1[CH3:9])=[O:5]参加物
6
実験手順
To 2-bromomethyl-3-methylmaleic anhydride (1.25 g, 6.10 mmol) was added 5 M aqueous sodium hydroxide solution (4 mL) at room temperature, and the mixture was stirred for 12 h. The reaction mixture was adjusted to pH 1 with 5 M hydrochloric acid (5 mL), added with sodium chloride and extracted three times with ethyl acetate. The combined organic layer was concentrated under reduced pressure, and the residue thus obtained was subjected to silica gel column chromatography (hexane-ethyl acetate 2:1) to give 227 mg of the title compound as oil (yield: 26%).
後処理
- extractionextracted three times with ethyl acetate
- concentrationThe combined organic layer was concentrated under reduced pressure
- customthe residue thus obtained
出典と根拠
- ORDレコード
- ord-251fecc967e14b808c91fed8ac5663f3
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260375B2
反応ノート
読み込み中…