Ethanesulfonamide → N-((5-Bromo-4-methylpyridin-3-yl)methyl)ethanesulfonamide
反応式
[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([CH:8]=O)[CH:5]=[N:6][CH:7]=1.[CH2:11]([S:13]([NH2:16])(=[O:15])=[O:14])[CH3:12].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([CH2:8][NH:16][S:13]([CH2:11][CH3:12])(=[O:15])=[O:14])[CH:5]=[N:6][CH:7]=1参加物
5
実験手順
In analogy to the procedure described for the preparation of intermediate A-11, 5-bromo-4-methyl-pyridine-3-carbaldehyde has been reacted first with ethanesulfonamide, followed by reduction of the thus formed imine with NaBH4 in MeOH to give the title compound as an off-white solid. MS: 293.1 and 295.3 (M+H+).
出典と根拠
- ORDレコード
- ord-f63f27579531424d8241278eb80c00e8
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260408B2
反応ノート
読み込み中…