[Br:1][C:2]1[C:3]([CH3:16])=[C:4](/[CH:8]=[N:9]/[S@@:10]([C:12]([CH3:15])([CH3:14])[CH3:13])=[O:11])[CH:5]=[N:6][CH:7]=1.CC([S@](N)=O)(C)C.BrC1C(C)=C(C=O)C=NC=1.[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([CH3:16])=[C:4]([CH2:8][NH:9][S@@:10]([C:12]([CH3:14])([CH3:13])[CH3:15])=[O:11])[CH:5]=[N:6][CH:7]=1(R)-2-Methyl-propane-2-sulfinic acid 1-(5-bromo-4-methyl-pyridin-3-yl)-meth-(E)-ylideneamide, prepared from (R)-2-methylpropane-2-sulfinamide and 5-bromo-4-methyl-pyridine-3-carbaldehyde in analogy to procedure described for the preparation of intermediate A-35 [A], has been reduced with NaBH4 in MeOH in analogy to the procedure described for the preparation of intermediate A-35 [B] to give the title compound as colorless solid. MS: 305.3 and 307.4 (M+H+).
読み込み中…