4-Methyl-5-nitro-2,3'-bipyridine → 4-Methyl-6-(pyridin-3-yl)pyridin-3-amine
反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:3]=1.[H][H]>[Pd].CO>[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[C:4]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:3]=1参加物
5
実験手順
A mixture of 4-methyl-5-nitro-2,3′-bipyridine (215 g, 1 mol), Pd/C (10 g, 10%) and MeOH (1000 mL) was stirred at room temperature for 16 h under 10 atm of hydrogen. After reaction, the mixture was filtered. The filtrate was evaporated at reduced pressure to afford 4-methyl-2,3′-bipyridin-5-amine as a yellow solid (152 g, 82%)
後処理
- customAfter reaction
- filtrationthe mixture was filtered
- customThe filtrate was evaporated at reduced pressure
出典と根拠
- ORDレコード
- ord-e0ac3da9f5c349a2bf79d375b9dcf18f
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260425B2
反応ノート
読み込み中…