Water → HCID 178419284、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.C1C(=O)N([I:18])C(=O)C1.O>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:10]([I:18])=[N:9][NH:8][C:5]2=[CH:6][N:7]=1参加物
5
実験手順
A solution containing 5-bromo-1H-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S2O5. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine.
後処理
- filtrationthen filtered
- washThe solid was washed with water and 5% Na2S2O5
- dry with materialThe crude product was dried under high vacuum overnight
出典と根拠
- ORDレコード
- ord-849bcbca85004f7cad2bcf9fa1ac2de1
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260425B2
反応ノート
読み込み中…