Hydrochloric Acid → 3-((4-Propylcyclohexyl)cyclohexyl)phenyl propanoate

HRID 17751ノート

反応式

HRID 17751 の反応式
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[CH2:6]([CH:9]1[CH2:14][CH2:13][CH:12]([C:15]2([C:21]3[CH:22]=[C:23]([OH:27])[CH:24]=[CH:25][CH:26]=3)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)[CH2:7][CH3:8].O.Cl>N1C=CC=CC=1>[C:1]([O:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:15]2([CH:12]3[CH2:13][CH2:14][CH:9]([CH2:6][CH2:7][CH3:8])[CH2:10][CH2:11]3)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH:22]=1)(=[O:4])[CH2:2][CH3:3]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 62324Propionyl chlorideHCID 684282843-((4-Propylcyclohexyl)cyclohexyl)phenol

生成物 1

HCID 684297793-((4-Propylcyclohexyl)cyclohexyl)phenyl propanoate収率 109.9%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Under a nitrogen atmosphere, 1.7 g of propanoyl chloride was added to 5.0 g of 3-((4-propylcyclohexyl)cyclohexyl)phenol (3) dissolved in 10 mL of pyridine under cooling with iced water, and after completing dropwise addition, the mixture was stirred at ambient temperature for 2 hours. The resulting solution was added to 20 mL of 3N hydrochloric acid. The aqueous layer was extracted with diethyl ether, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 6.52 g of 3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate (4).

後処理

  1. additionaddition
  2. extractionThe aqueous layer was extracted with diethyl ether, which
  3. additionwas added to the organic layer
  4. washthe organic layer was washed with a saturated salt solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. distillationThe solvent was distilled off

出典と根拠

ORDレコード
ord-40c8bef0bc5d470f8c1c4b99c8dc2dc8
出典データセット
uspto-grants-2010_06
特許番号
US07740769B2

反応ノート

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