Water → 5-iodo-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine
反応式
[CH3:1][O:2][C:3]1[C:4]2[CH:11]=[CH:10][NH:9][C:5]=2[N:6]=[CH:7][N:8]=1.[I:12]N1C(=O)CCC1=O.O>ClCCl>[I:12][C:11]1[C:4]2[C:3]([O:2][CH3:1])=[N:8][CH:7]=[N:6][C:5]=2[NH:9][CH:10]=1参加物
5
実験手順
To 4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (3, 3.20 g, 21.4 mmol) in 280 mL of dichloromethane, N-iodosuccinimide (5.3 g, 24.0 mmol) suspended in dichloromethane was added. The reaction was stirred at room temperature for 2 hours, then poured into water and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and the filtrate concentrated under vacuum. The resulting material was washed with ethyl acetate and hexane to provide the desired compound (35, 4.80 g).
後処理
- additionwas added
- extractionextracted with ethyl acetate
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationthe filtrate concentrated under vacuum
- washThe resulting material was washed with ethyl acetate and hexane
出典と根拠
- ORDレコード
- ord-b42c1f0142bd47a1bbc6c4279754ce85
- 出典データセット
- uspto-grants-2016_02
- 特許番号
- US09260437B2
反応ノート
読み込み中…