1-(4-Bromo-3-methylphenyl)ethanone → 2-Bromo-1-(4-bromo-3-methylphenyl)ethanone

HRID 1776025

反応式

HRID 1776025 の反応式
[Br-:1].[Br-].[Br-].C[N+](C)(C)C1C=CC=CC=1.C[N+](C1C=CC=CC=1)(C)C.C[N+](C1C=CC=CC=1)(C)C.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([C:41](=[O:43])[CH3:42])=[CH:37][C:36]=1[CH3:44]>C1COCC1>[Br:1][CH2:42][C:41]([C:38]1[CH:39]=[CH:40][C:35]([Br:34])=[C:36]([CH3:44])[CH:37]=1)=[O:43]

参加物

4

反応物 2

HCID 3471241-(4-Bromo-3-methylphenyl)ethanoneHCID 17977687Phenyltrimethylammonium bromide dibromide

生成物 1

HCID 591663462-Bromo-1-(4-bromo-3-methylphenyl)ethanone収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Trimethyl phenylammonium tribromide (13 g, 0.036 mol) was added to a solution of 1-(4-bromo-3-methyl-phenyl)-ethanone (6.3 g, 0.030 mol) in THF (30 mL) and the reaction mixture was stirred at RT for 12 h, filtered, and concentrated to provide the title intermediate (8.6 g, 100% yield). 1H NMR (CDCl3, 400 MHz) δ (ppm): 7.82 (m, 1H), 7.66 (m, 2H), 4.38 (s, 2H), 2.56 (s, 3H)

後処理

  1. filtrationfiltered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-f045d3a9eb774e919dd2222e64f2203e
出典データセット
uspto-grants-2016_02
特許番号
US09260414B2

関連ノート

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