Sodium Hydroxide → 3-(4-(Methylthio)phenylamino)-3-oxopropanoic acid

HRID 1776492ノート

反応式

HRID 1776492 の反応式
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]([O:14]CC2C=CC=CC=2)=[O:13])=[CH:5][CH:4]=1.[OH-].[Na+]>CO.Cl>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:22])[CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 86679443Benzyl 3-(4-(methylthio)phenylamino)-3-oxopropanoate

生成物 1

HCID 622307273-(4-(Methylthio)phenylamino)-3-oxopropanoic acid収率 84%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

Benzyl 3-(4-(methylthio)phenylamino)-3-oxopropanoate (150 mg, 0.476 mmol) was dissolved in MeOH (1.5 ml). NaOH 1M (500 μl) was added, and the reaction was stirred at 40° C. for 2 hours to achieve completion. The reaction mixture was diluted with HCl 1N and extracted with EtOAc. The organic phase was washed with HCl 1N and brine, dried over Na2SO4 and concentrated under vacuum to give 3-(4-(methylthio)phenylamino)-3-oxopropanoic acid (90 mg, 84% yield).

後処理

  1. extractionextracted with EtOAc
  2. washThe organic phase was washed with HCl 1N and brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-dd585cbeb5314c6481e7a600d75e718f
出典データセット
uspto-grants-2016_02
特許番号
US09265768B2

反応ノート

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