Pyridine → Ethyl 4-methoxy-3-(methylsulfonamido)phenyl carbonate

HRID 1776588ノート

反応式

HRID 1776588 の反応式
[C:1](=[O:15])([O:12][CH2:13][CH3:14])[O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([NH2:11])[CH:4]=1.N1C=CC=CC=1.[CH3:22][S:23](Cl)(=[O:25])=[O:24]>C(Cl)Cl>[C:1](=[O:15])([O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([NH:11][S:23]([CH3:22])(=[O:25])=[O:24])[CH:4]=1)[O:12][CH2:13][CH3:14]

参加物

5

反応物 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 134556543-Amino-4-methoxyphenyl ethyl carbonate

生成物 1

HCID 86679540Ethyl 4-methoxy-3-(methylsulfonamido)phenyl carbonate収率 95.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 3-amino-4-methoxyphenyl ethyl carbonate (0.650 g, 3.08 mmol) and pyridine (2.2 ml, 27.2 mmol) in dry DCM (20 ml), methanesulfonyl chloride (1.0 ml, 12.83 mmol) was added at RT, and the resulting mixture was stirred for 3 hours. The volatiles were removed under reduced pressure affording crude ethyl 4-methoxy-3-(methylsulfonamido)phenyl carbonate (0.850 g, 2.94 mmol, 95% yield, MS/ESI+312.1 [MNa]+) which was used for the next step without purification.

後処理

  1. customThe volatiles were removed under reduced pressure

出典と根拠

ORDレコード
ord-bab5a4184e9d4eafbb68d22917e4a23f
出典データセット
uspto-grants-2016_02
特許番号
US09265768B2

反応ノート

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