Sodium Hydroxide → 2-[2-(Methylsulfonyl)phenoxy]acetic acid

HRID 1777133ノート

反応式

HRID 1777133 の反応式
[CH3:1][S:2]([C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10])(=[O:4])=[O:3].[OH-].[Na+]>CCO>[CH3:1][S:2]([C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[O:7][CH2:8][C:9]([OH:11])=[O:10])(=[O:3])=[O:4]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86729449Ethyl 2-(2-(methylsulfonyl)phenoxy)acetate

生成物 1

HCID 232741362-[2-(Methylsulfonyl)phenoxy]acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 2-(2-(methylsulfonyl)phenoxy)acetate (750 mg, 2.9 mmol) in EtOH (15 ml) was added 10% NaOH aqueous solution (15 mL) at 26° C. The mixture was stirred for 30 min and then concentrated and the residue diluted with water (20 mL) and washed with ethyl acetate (2×20 mL). The aqueous layer was then acidified with 2N HCL until pH 3 and then extracted with ethyl acetate (2×20 ml). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

後処理

  1. concentrationconcentrated
  2. additionthe residue diluted with water (20 mL)
  3. washwashed with ethyl acetate (2×20 mL)
  4. extractionextracted with ethyl acetate (2×20 ml)
  5. washThe combined organic layers were washed with brine (30 mL)
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-d08681aa5c65423f8d4dfafcb2d8ae4e
出典データセット
uspto-grants-2016_02
特許番号
US09266836B2

反応ノート

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