HCID 69559116、化合物 → HCID 59327423、化合物

反応式

[CH2:1]([O:3][C:4]([C:6]1([CH2:19][C:20]([CH3:22])=[CH2:21])[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]([C:6]1([CH2:19][CH:20]([CH3:21])[CH3:22])[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

参加物

実験手順

5% Pd/C (0.3 g, 50% wet) is added to a solution of 4-(2-methylallyl)piperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester (1.0 g, 0.0032 mol) in ethanol (10 mL). The reaction mixture is stirred under the positive pressure of hydrogen gas for 1 hr at room temperature. The reaction mixture is filtered through celite bed and washed with ethanol (15 mL). Combine filtrate is concentrated under reduced pressure to get 4-isobutylpiperidine-1,4-dicarboxylic acid-1-tert-butyl ester-4-ethyl ester.